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Anti convulsant induction of CYP3A4 has been shown to affect the pharmacodynamics of paclitaxel, irinotecan and tenipisode and concomitant administration of anti convulsants with chemotherapy has been associated with a worse disease free survival in children with acute lymphoblastic leukaemia . Table 6 lists commonly used drugs which may interfere with cytotoxic drug elimination, focusing on the CYP3A4/MDR1 axis since this is the major elimination route for most cytotoxic drugs and the site of most potential drug interactions.
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